Description
PhD and Master projects are available addressing questions of cytoskeleton self-organization and dynamics.
The lab of Thomas Surrey is interested in the question of biological self-organization, studying how the cytoskeleton of living cells builds itself. The goal is to understand in a quantitative manner biological network behaviour based on physico-chemical principles. The lab uses a bottom-up synthetic biology approach and has pioneered a number of novel microscopy-based in vitro reconstitutions that provide insight into the molecular mechanisms underlying microtubule cytoskeleton organization, dynamics and function.
In the projects, a combination of advanced biochemical in vitro reconstitutions, modern microscopy (down to single molecules) and microfabrication will be used to understand the design principles of cytoskeleton organization by building a mini-cytoskeleton from purified components. The lab is currently particularly interested in the role of motor proteins such as dynein and kinesin and, the effects of molecular crowding and spatial micro-confinement for active matter self-organization. Using molecules that build the mitotic spindle in cells, the projects will contribute to a better mechanistic understanding of how biological function emerges from active matter.
We are looking for students who have a strong interest in academic research and enjoy working in an interdisciplinary environment with state-of-the-art facilities. Highly motivated candidates with an interest in the interface between biochemistry, cell biology, biophysics and material science are encouraged to apply by sending a motivation letter, a CV, and names and contact details of two referees.
About Centre for Genomic Regulation (CRG)
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from over 40 countries. The CRG provides an international and interdisciplinary research environment with laboratories that are leaders in their field, supported by high-end technology platforms.
